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After initiation of Avandia, and after dose increases, observe patients carefully for signs and symptoms of heart failure (including excessive, rapid weight gain, dyspnea, and/or edema). "Across the extensive dataset for Avandia, GlaxoSmithKline believes there is no consistent or systematic evidence that Avandia increases the risk of heart attack or cardiovascular death in comparison to other anti-diabetic medicines," the company said in a prepared statement. Therefore, Avandia should not be used in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis. 11 -- A controversial drug called Avandia, used by millions of diabetics to control blood sugar, greatly increases their risk of heart attack and heart failure, researchers report. Three other studies (mean duration 41 months; 14,067 total patients), comparing Avandia to some other approved oral antidiabetic agents or placebo, have not confirmed or excluded this risk.

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